Biologists Have Identified A Rare Mutation Associated With Type 2 Diabetes
British geneticists have discovered a rare variant of the GIGYF1 gene, which increases the likelihood of developing type 2 diabetes. It occurs in about 0.033% of the inhabitants of the Earth. The description of the study is available in the scientific journal Nature Communications.
According to statistics from the World Health Organization, approximately 463 million people suffer from type I and type II diabetes. In order not to die or go to the hospital, they are forced to constantly take insulin.
In a new study, British geneticists led by John Perry from the University of Cambridge have discovered one of the rarest, but at the same time significant mutations, due to which a patient may have type 2 diabetes and metabolic disorders that lead to it.
Scientists worked with data from the UK Biobank project, for which about 400 thousand Britons provide their DNA, undergo a medical examination, and talk about food preferences and bad habits. Perry and his colleagues studied the varieties of genes characteristic of diabetics. In total, they analyzed the medical records of more than 200 thousand project participants.
Researchers have discovered a rare mutation that caused cells of the immune system and other parts of the human body to age faster. It also increased the likelihood of developing type 2 diabetes by about six times. This variation of the GIGYF1 gene is several times higher than all known mutations in other genes that are associated with diabetes and the resulting metabolic syndrome.
How exactly this variant of GIGYF1 increases the likelihood of developing diabetes, scientists can not yet say. They suggest that this mutation disrupts the ability of cells to respond normally to a decrease or increase in the concentration of insulin in the body. Perry and his colleagues hope that further experiments on cell cultures will help to test this idea.